Bulletin of the World Health Organization

Putting the priorities first: medicines for maternal and child health

Suzanne R Hill

Volume 90, Number 3, March 2012, 236-238

Table 2. “Wish list” of priority medicines for mothers and children

Type of product needed Optimal dosage regimen
Tuberculosis: development of a product that will deliver these doses when given in 0.5 to 2.0 tablets per day over the weight range 5–30kg. For example, a fixed-dose combination containing rifampicin 250 mg, isoniazid 150 mg, pyrazinamide 400 mg and ethambutol 250 mg. Ethambutol: 20 mg/kg/day (15 mg–25 mg/kg/day)
Rifampicin: 15 mg/kg/day (10–20 mg/kg/day)
Isoniazid: 10 mg/kg/day (10–15 mg/kg/day)
Pyrazinamide: 35 mg/kg/day (30–40 mg/kg/day)
HIV, TB prophylaxis, Pneumocystis carinii pneumonia: development of a fixed-dose combination product of appropriate strength. Isoniazid/co-trimoxazole
Neonatal care:
     apnoea: availability of a fully commercialized quality product in more countries; determination of the regulatory pathway; and dissemination of information on use. Caffeine citrate: liquid 20mg/ml
     cord care: availability of a fully commercialized quality product in more countries; determination of the regulatory pathway; establishment of optimal product types. Chlorhexidine digluconate: solution, 4%
     vitamin K deficiency: identification of optimal dose and strength of injection. Vitamin K