Pandemic Influenza Preparedness (PIP) Framework

What is the PIP Framework?

The PIP Framework brings together Member States, industry, other stakeholders and WHO to implement a global approach to pandemic influenza preparedness and response. Its key goals include: to improve and strengthen the sharing of influenza viruses with human pandemic potential; and to increase the access of developing countries to vaccines and other pandemic related supplies. The Framework was developed by Member States. It came into effect on 24 May 2011 when it was unanimously adopted by the Sixty-fourth World Health Assembly (2011)

WHO/Jermias da Cruz. Partnership Contribution funded training in Infection Prevention Control, Timor Leste

Partnership Contribution

The annual Partnership Contribution (PC) is a cash contribution of US$ 28 million given to WHO by influenza vaccine, diagnostic and pharmaceutical manufacturers that use the WHO Global Influenza Surveillance and Response System. This money is used to prepare for--and respond to--an influenza pandemic.


The Standard Material Transfer Agreement 2 (SMTA2) is an advance supply contract that gives WHO predictable access to vaccine and other products needed during the response to the next influenza pandemic. WHO signs these contracts with manufacturers, research institutions, or other entities that receive PIP Biological Materials (PIPBM)--or, in some cases, benefit from the use of PIPBM--from a laboratory which is part of the Global Influenza Surveillance and Response System (GISRS).


The PIP Framework has a three-pronged governance structure:

  • The World Health Assembly that oversees implementation of the PIP Framework;
  • The Director-General who promotes implementation of the Framework and advises the World Health Assembly; and,
  • The PIP Framework Advisory Group that monitors the implementation of the PIP Framework and provides guidance to the Director-General.

Virus Sharing

Influenza virus sharing, conducted by the WHO Global Influenza Surveillance and Response System (GISRS), is vital to global pandemic preparedness. The sharing of viruses facilitates pandemic risk assessment, the development of candidate vaccine viruses, updating of diagnostic reagents and test kits, and surveillance for resistance to antiviral medicines.

Key Documents & Links

The page below contains a number of key PIP Framework-related documents and links, such as:

  • Questions and Answers on the PIP Framework
  • PIP Framework infographic
  • A list of PIP Framework-related publications in academic journals and other publications
  • PIP and Influenza@WHO newsletters
  • Link to the webpage on public health implications of implementation of the Nagoya Protocol

Upcoming Events

146th Session of WHO Executive Board
3-8 February 2020

PIP AG Consultation with Stakeholders
18 March 2020

Contact us

PIP Framework Secretariat